Electrical Sensing of sickled red blood cells subpopulations in microfluidic device

AUTHORS

Xu Tieying
Lizarralde-Iragorri Maria A
Roman Jean
Martincic Emile
Brousse Valentine
Français Olivier
El Nemer Wassim
Le Pioufle Bruno

KEYWORDS

Sickle Cell Disease

Electrical Sensing

Microfluidic

Document type

Conference papers

Résumé

This paper discusses the electrical sensing of red blood cell (RBC) rigidity due to Hemoglobin S (HbS) polymerization in sickle cell disease. For this purpose sickle RBCs subpopulations, differentiated by cell density, were flown through a microfluidic device equipped with integrated microelectrodes. Differences in transit time and electrical blockade were observed and analyzed.

FILE

MORE INFORMATION